“Hazard Identification" is the determination of whether a situation poses a threat to human health or the environment. A threatening situation may be natural (e.g. volcanos) or man-made. STPP focuses on identifying man-made hazards associated with chemicals, products and industrial processes. Once a chemical is identified as hazardous, STPP turns its attention to identifying safer substitutes through alternatives analysis and promoting the diffusion of safer substitutes through law and policy.
Key issues associated with hazard identification, include:
•What adverse health or environmental effects are associated with each of the agents of potential interest?
•What is the level of evidence required to support the classification of each adverse effect?
•How do we establish causality?
•What are valid approaches to evaluating susceptibility?
STPP is actively involved in defining the science of hazard identification which includes multidisciplinary approaches such as toxicology, epidemiology, in vitro assays, mechanistic studies and case studies. STPP is employing new methods in toxicity testing – including early step analysis and determination of whether chemicals are harmful to public health. STPP is specifically interested in advancing the science of predictive toxicology--the ability to predict which chemical is likely to be toxic or benign based on the structure of the chemical--as well as mechanistic toxicology--how chemicals create biological changes which later result in an adverse health outcome.
STPP supports a full spectrum of methodologies, including the new paradigm in toxicity testing as defined by the National Research Council Report Toxicity Testing in the 21st Century: A Vision and a Strategy.
Click here to see what STPP is doing in this area.